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An additional two doses of 2.5 gms (total 5 gms) may be administered if the coagulation profile is abnormal or the patient is actively bleeding, or another surgical procedure is required.5 gms administered intravenously as two separate doses of 2.5 gms each no more than 15 minutes apart.Idarucizumab (Praxbind) Dose in Adults: Idarucizumab (Praxbind) Dose in the treatment of reversal of dabigatran: It is indicated to reverse the anticoagulant effects of dabigatran in patients with uncontrolled or life-threatening bleeding, and in patients undergoing an emergency procedure.Idarucizumab (Praxbind) is a humanized monoclonal antibody that is used to reverse the effects of dabigatran. Further clinical data will help to understand the clinical impact of rapid reversal on the outcome of bleeding patients.Vaccines & immunoglobulins Vitamins Gout treatment Featured Video Consultation Idarucizumab rapidly and completely reverses the anticoagulant effect of dabigatran in vitro, in healthy volunteers, and in patients presenting with severe bleeding or requiring urgent procedures. While most of these situations can be managed without the need for a reversal agent, the ability to promptly switch off anticoagulant activity is likely beneficial in severe bleeding situations and can help to avoid delays and improve safety in the management of patients requiring urgent procedures. Non-vitamin K oral anticoagulants (NOACs) are associated with a reduced risk of major and life-threatening bleeding compared to warfarin, but the absence of a specific reversal agent has caused concern among clinicians.Īreas covered: This article describes the indications for and practical use of idarucizumab, a specific reversal agent for the direct thrombin inhibitor dabigatran.Įxpert commentary: Each year, 3-5% of anticoagulated patients will experience major bleeding and about 10% will require invasive interventions. However, interfering with the coagulation system increases the risk of bleeding. Introduction: Anticoagulants are highly effective in reducing the risk of embolism in patients with atrial fibrillation and in the treatment of venous thromboembolism.